Brad Runyon is on his way to join a friend, but has car trouble and hitches a ride with a former soldier who tells of a grudge he has against his former major, and Runyon suspects he means to kill him, so he follows and prevents the murder, but the major is killed anyway.
Gracie Allen tells George she would never miss Jack's program for anything in the world, but keeps turning it on and off. Gracie visits Jack's program to impersonate Lauren Bacall who couldn't make it to the show the previous week.
News of The Week reports on New York City's loan shark racket. Fred jokes with Portland about Jack Benny's new film, Buck Benny Rides Again. Fred interviews a man who makes clothes for dogs. The question for The Round Table is "In What Form Do You Most Enjoy A Good Story?" Peter Van Steeden insists Fred celebrate Peter's 5th anniversary on the program, so Fred has The Mighty Allen Art Players perform a play called "From Nipper To Nobody," or "Van Steeden Didn't Curse The Day He Was Born, But Everyone Else Did."
Don Ameche introduces Mario Lanza who sings, "Cosi, Cosa," to kick off this 2 hour 7th annual Thanksgiving program sponsored by the Elgin Watch Company. Don gives Garry Moore jokes to read, but Garry says that quiz shows are more popular these days. Garry and Jimmy Durante joke about Thanksgiving. Jimmy sings "Inka Dinka Do." Jack Benny gets a lift from Don to shop for a turkey. Vera Vague and Frances Langford trade insults. Vera Vague flirts with Dean Martin and insults Jerry Lewis. Don Ameche and Frances Langford perform a Bickersons skit. Red Skelton as The Mean Widdle Kid, is accused of stealing Thanksgiving food, but has a very good reason.
Rosemary sings, "It's A Most Unusual Day." Bing talks about someone trying to produce a cross between a chicken and a turkey. Rosemary sings, "Bye Bye Black Bird." Bing and Rosemary sing, "Isn't It A Lovely Day."
Jack Benny complains to host Dick Powell that everyone is surprised to see him on the show. Mary Martin tells Jack he's not the big movie star he once was, after he insists that the Paramount premiere of his new film with Fred Allen be made in his own hometown, instead of Allen's. Mary sings a song co-written by Meredith Wilson and Charlie Chaplin. Daddy tries to explain holidays and the story of Thanksgiving to Baby Snooks.
Al Jolson sings "California, Here I Come." Oscar Levant tells Al his wife wants to get into politics, then performs a melody from Chopin. Oscar complains about being hungry while other people have already eaten their Thanksgiving dinner. Dorothy Lamour visits, and Al wants to do a Road Picture with her, then tries to make love to her.
Don Ameche hosts this 2 hour Thanksgiving special sponsored by the Elgin Watch Company. Among some of the performing stars are Garry Moore, Jimmy Durante, Candy Candido, Larry Storch, Vera Vague, Jack Benny, Red Skelton as both Junior The Mean Widdle Kid, and Clem Kaddiddlehopper, Artie Auerbach as Mr. Kitzel, and others.
Jack arrives at the CBS studio to do his show, only to find Bergen and McCarthy have been given his dressing room. Then he finds Amos and Andy have been given another dressing room supposedly assigned to him. Jack meets Red Skelton rehearsing his act, then learns Red has been given Jack's studio.
The sponsor sends Fred a new Program Creator to create a whole new program. Fred has a new quiz show segment with audience members. Fred tries to interview character actor Ned Sparks, but they start off insulting each other. The Mighty Allen Art Players perform the true story of Stanley and Livingston, with a joke about Jack Benny at the end.
Humphrey Bogart and Lauren Bacall star in this Lux adaptation of the film; To Have And Have Not, about a charter boat captain who finds himself in a developing romance, while becoming involved with the Free French Resistance.
Poirot arrives at his apartment to find a runaway bride hiding inside from a man she refuses to marry. Poirot discovers the man who is determined to marry the woman is in fact a murderer, and sets a trap for him.
Doctor Watson recounts the final days of his good friend Sherlock Holmes in the confrontation between Holmes and Professor Moriarty at the Reichenbach Falls in Switzerland. Orson Welles as Professor Moriarty.
Bob makes fun of how wrong the polls were in predicting that Dewey would beat Truman to become president. A behind the scenes look at how Paramount reacted to Hope's accident. Jack Benny visits Bob to try and sell him an insurance policy. Bob and Jack pretend to be disk jockeys.
Host Cecil B. DeMille introduces Alan Ladd and Hedy Lamar as the stars of the Lux production of Casablanca, about the leader of the Nazi resistance and his wife who seek to escape the Nazis with an exit visa held by the owner of a cafe.